Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006925 | 0.89 | KCNJ1 (0.37) | KCNJ1KCNH2NOS3NOS1NOS2 | |
| SCHEMBL12380552 | 0.76 | NPC1 (0.49) | KCNJ1KCNH2KDM4EALDH1A1MAPT | |
| SCHEMBL1231574 | 0.74 | TSHR (0.57) | ALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL12380568 | 0.68 | CHKA (0.56) | KCNJ1KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL456337 | 0.67 | ALDH1A1 (0.44) | ALDH1A1XDHSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7003806 | 0.67 | KMT2A (0.41) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13181116 | 0.67 | GAA (0.53) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL7003402 | 0.66 | MAPK1 (0.41) | KCNH2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4694901 | 0.65 | AR (0.57) | KDM4EALDH1A1XDHARHPGD | |
| SCHEMBL1197763 | 0.64 | MAPT (0.54) | NOS2KDM4EALDH1A1XDHAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292586-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIMIDINONES | Pfizer Limited (GB) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098284-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIMIDINONES | PFIZER LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |