Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.63 |
| ▸ | ECE1 | P42892 | 6/20 | 0.57 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.54 |
| ▸ | EDNRA | P25101 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP9 | P14780 | 4/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | IL1RN | P18510 | 3/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.52 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | MMP15 | P51511 | 1/20 | 0.52 |
| ▸ | MMP16 | P51512 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11016816 | 0.86 | CTSL (0.69) | CTSLECE1ACE | |
| SCHEMBL7123258 | 0.86 | CTSL (0.71) | CTSLACE | |
| SCHEMBL13254023 | 0.86 | CTSL (0.71) | CTSLACE | |
| SCHEMBL29434560 | 0.86 | IL1RN (0.54) | CTSLERAP2EDNRAMMP2MMP9 | |
| SCHEMBL15393705 | 0.84 | ECE1 (0.52) | CTSLECE1ERAP2MMP2MMP9 | |
| SCHEMBL31094974 | 0.84 | ECE1 (0.65) | ECE1ERAP2EDNRAMMP2MMP9 | |
| SCHEMBL29434598 | 0.82 | EDNRA (0.65) | ECE1ERAP2EDNRAMMP2MMP9 | |
| SCHEMBL8742301 | 0.82 | CCKBR (0.59) | CTSLECE1ERAP2MMP2MMP8 | |
| SCHEMBL16330216 | 0.82 | CTSL (0.66) | CTSLEDNRAACE | |
| SCHEMBL14648801 | 0.82 | CTSL (0.66) | CTSLEDNRAACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611756-B1 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-5955491-A | ADMINISTERING CATHEPSIN L INHIBITOR AND BONE RESORPTION INHIBITOR CONTAINING AN ALCOHOL OR ALDEHYDE DERIVATIVE, OR SALT THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |
| US-5716980-A | PROPHYLACTIC, THERAPY FOR OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| US-5639781-A | PREVENT REABSORPTION OF BONE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| US-5498728-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0611756-A2 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |