Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315891 | 0.70 | CYP2C19 (0.33) | TSHRNFKB1CYP2C19 | |
| SCHEMBL6747801 | 0.64 | — | — | |
| SCHEMBL21457842 | 0.59 | NR3C1 (0.40) | TSHRNFKB1CYP2C19 | |
| SCHEMBL14826670 | 0.58 | SMN1; SMN2 (0.52) | TSHR | |
| SCHEMBL21457838 | 0.58 | NR3C1 (0.40) | — | |
| SCHEMBL27628591 | 0.58 | ALDH1A1 (0.37) | — | |
| SCHEMBL20572985 | 0.58 | SLC1A2 (0.36) | TSHR | |
| SCHEMBL27961792 | 0.58 | TSHR (0.57) | TSHRNFKB1CYP2C19 | |
| SCHEMBL18952262 | 0.58 | TSHR (0.42) | TSHRNFKB1CYP2C19 | |
| SCHEMBL18220604 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |