Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 12/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749436 | 0.87 | UBE2M (0.34) | ICAM1HDAC6 | |
| SCHEMBL8322460 | 0.83 | ICAM1 (0.40) | ICAM1HDAC6 | |
| SCHEMBL6749560 | 0.75 | ICAM1 (0.47) | ICAM1 | |
| SCHEMBL6747454 | 0.74 | HDAC6 (0.43) | ICAM1HDAC6LMNA | |
| SCHEMBL6745329 | 0.73 | ICAM1 (0.37) | ICAM1HDAC6 | |
| SCHEMBL6749064 | 0.73 | HDAC6 (0.41) | ICAM1HDAC6 | |
| SCHEMBL6745847 | 0.73 | HDAC6 (0.37) | HDAC6LMNA | |
| SCHEMBL6747276 | 0.72 | HDAC6 (0.42) | ICAM1HDAC6LMNA | |
| SCHEMBL6751892 | 0.72 | ICAM1 (0.43) | ICAM1 | |
| SCHEMBL6751888 | 0.72 | ICAM1 (0.43) | ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0934941-A1 | BENZOPIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-08-11 | — | — | EP | disclosed |