Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141895 | 1.00 | SLC1A3 (0.50) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL7137510 | 0.86 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL7137507 | 0.86 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL8742354 | 0.86 | CYP3A4 (0.49) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL8742351 | 0.86 | CYP3A4 (0.49) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL3354730 | 0.83 | SLC1A3 (0.67) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL3354732 | 0.83 | SLC1A3 (0.67) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL7138604 | 0.82 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL7142626 | 0.81 | CASP1 (0.47) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 | |
| SCHEMBL7142623 | 0.81 | CASP1 (0.47) | SLC1A3SLC1A2SLC1A1ADAM17KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611756-B1 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-5955491-A | ADMINISTERING CATHEPSIN L INHIBITOR AND BONE RESORPTION INHIBITOR CONTAINING AN ALCOHOL OR ALDEHYDE DERIVATIVE, OR SALT THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |
| US-5716980-A | PROPHYLACTIC, THERAPY FOR OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0783489-A1 | ALDEHYDE DERIVATIVES AS UPSTEINE PROTEASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| US-5639781-A | PREVENT REABSORPTION OF BONE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| WO-1996010014-A1 | ALDEHYDE DERIVATIVES AS UPSTEINE PROTEASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-04-04 | — | — | WO | disclosed |
| US-5498728-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0611756-A2 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |