Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138021 | 0.86 | KDM4D (0.35) | KDM4DABL1L3MBTL1ROCK2CCR3 | |
| SCHEMBL7146597 | 0.85 | ADH5 (0.41) | KDM4DABL1L3MBTL1PDE4APDE4B | |
| SCHEMBL7143394 | 0.84 | ADH5 (0.40) | KDM4DABL1L3MBTL1PDE4APDE4B | |
| SCHEMBL7703166 | 0.84 | VCP (0.34) | ABL1CCR3BACE1 | |
| SCHEMBL7147242 | 0.83 | ABL1 (0.41) | KDM4DABL1L3MBTL1PDE4APDE4B | |
| SCHEMBL7139934 | 0.83 | ABL1 (0.41) | KDM4DABL1L3MBTL1PDE4APDE4B | |
| SCHEMBL7144093 | 0.83 | KDM4D (0.36) | KDM4DABL1L3MBTL1CCKBRCCR3 | |
| SCHEMBL7141841 | 0.83 | KDM4D (0.35) | KDM4DABL1L3MBTL1CCKBRCCR3 | |
| SCHEMBL5868843 | 0.82 | CYP17A1 (0.42) | KDM4DABL1L3MBTL1PDE4APDE4B | |
| SCHEMBL7139808 | 0.82 | ABL1 (0.39) | KDM4DABL1L3MBTL1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |