Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141976 | 1.00 | P2RX1 (0.36) | P2RX1P2RX4P2RX7HIF1AMAOB | |
| SCHEMBL7136435 | 0.90 | TRPA1 (0.42) | MAOB | |
| SCHEMBL7142991 | 0.84 | KDM4E (0.38) | MAOBKDM4EHTTMAPT | |
| SCHEMBL7142993 | 0.84 | KDM4E (0.38) | MAOBKDM4EHTTMAPT | |
| SCHEMBL7136429 | 0.84 | MAOB (0.41) | MAOBKDM4EHTTMAPT | |
| SCHEMBL7136425 | 0.84 | MAOB (0.41) | MAOBKDM4EHTTMAPT | |
| SCHEMBL7144373 | 0.82 | MAOB (0.44) | MAOBKDM4EHTTMAPT | |
| SCHEMBL7144375 | 0.82 | MAOB (0.44) | MAOBKDM4EHTTMAPT | |
| SCHEMBL7139075 | 0.81 | TRPV1 (0.42) | MAOBMAPT | |
| SCHEMBL7139073 | 0.81 | TRPV1 (0.42) | MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996439-B1 | BETA-ALKOXYACRYLATES AGAINST MALARIA | HOFFMANN LA ROCHE (CH) | 2003-01-08 | — | — | EP | disclosed |
| US-6084120-A | ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID | HOFFMANN-LA ROCHE INC. (US) | 2000-07-04 | — | — | US | disclosed |