Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136336 | 0.89 | HRH1 (0.38) | HRH1DRD2DRD3 | |
| SCHEMBL7139912 | 0.87 | HRH1 (0.44) | HRH1DRD2DRD3 | |
| SCHEMBL9284502 | 0.85 | HRH1 (0.43) | HRH1DRD2DRD3 | |
| Water SCHEMBL7159274 | 0.84 | HRH1 (0.43) | HRH1DRD2DRD3 | |
| SCHEMBL7140255 | 0.83 | THRB (0.36) | HRH1DRD2DRD3 | |
| SCHEMBL7144048 | 0.83 | HRH1 (0.34) | HRH1DRD2DRD3 | |
| SCHEMBL7139908 | 0.83 | UTS2R (0.35) | HRH1DRD2DRD3 | |
| SCHEMBL7140276 | 0.83 | HRH1 (0.34) | HRH1DRD2DRD3 | |
| SCHEMBL7144620 | 0.82 | HRH1 (0.38) | HRH1DRD2DRD3 | |
| SCHEMBL7138901 | 0.81 | HRH1 (0.54) | HRH1PNMTNOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672047-B1 | ANTIALLERGIC IMIDAZO[1,2-a]THIENO[ 2,3-d]AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-02 | — | — | EP | disclosed |
| US-5629308-A | Imidazo [1,2-A] (pyrrolo, thieno or furano) [2,3-D] azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-13 | — | — | US | disclosed |
| EP-0672047-A1 | ANTIALLERGIC IMIDAZO 1,2-a](PYRROLO, THIENO OR FURANO) 2,3-d]AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994013680-A1 | ANTIALLERGIC IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[2,3-d]AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |