Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9284502 | 0.89 | HRH1 (0.43) | HRH1HTR2AMAPTDRD3DRD2 | |
| Water SCHEMBL7159274 | 0.88 | HRH1 (0.43) | HRH1HTR2AMAPTDRD3DRD2 | |
| SCHEMBL8931334 | 0.87 | MAPT (0.36) | HRH1HTR2AMAPTDRD3DRD2 | |
| SCHEMBL7139908 | 0.85 | UTS2R (0.35) | HRH1HTR2ADRD3DRD2LMNA | |
| SCHEMBL7136336 | 0.84 | HRH1 (0.38) | HRH1HTR2ADRD3DRD2LMNA | |
| SCHEMBL8931351 | 0.84 | UTS2R (0.35) | HRH1MAPTDRD3TSHRALDH1A1 | |
| SCHEMBL7895280 | 0.83 | HRH1 (0.42) | HRH1HTR2AMAPTDRD3DRD2 | |
| SCHEMBL7139912 | 0.83 | HRH1 (0.44) | HRH1HTR2AMAPTDRD3DRD2 | |
| SCHEMBL7139634 | 0.83 | HRH1 (0.34) | HRH1HTR2ADRD3DRD2KCNA5 | |
| SCHEMBL7142052 | 0.82 | HRH1 (0.38) | HRH1DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672047-B1 | ANTIALLERGIC IMIDAZO[1,2-a]THIENO[ 2,3-d]AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-02 | — | — | EP | disclosed |
| US-5629308-A | Imidazo [1,2-A] (pyrrolo, thieno or furano) [2,3-D] azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-13 | — | — | US | disclosed |