SCHEMBL7142157

SCHEMBL7142157

C=CCC1CCCCN1Oc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.38
CHRNB4 P30926 1/20 0.38
CHRNA3 P32297 1/20 0.38
CHRNA7 P36544 1/20 0.38
CHRNA4 P43681 1/20 0.38
CHRM1 P11229 4/20 0.36
NPC1 O15118 1/20 0.36
HPGD P15428 1/20 0.36
RAB9A P51151 1/20 0.36
ADRA2A P08913 1/20 0.34
FFAR1 O14842 1/20 0.34
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8188491 0.80 NPC1 (0.50) NPC1HPGDRAB9AKDM4E
SCHEMBL503024 0.80 NPC1 (0.39) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL10935160 0.77 SLC6A2 (0.40)
SCHEMBL4101527 0.75 SPHK2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL7246915 0.75 NPC1 (0.45) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL4101521 0.75 SPHK2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL27543742 0.74 FFAR1 (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL22462974 0.73 KMT2A (0.42) CHRNB4CHRNA3HPGDKDM4E
SCHEMBL9282280 0.72 ALDH1A1 (0.38) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL11990439 0.72 OPRD1 (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0026876-B1 N-PHENOXYALKYLPIPERIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1983-02-16 EP claimed
US-4348401-A ANTIHISTAMINIC, ANTIEDEMIC, ANTIPHLOGISTIC BOEHRINGER MANNHEIM GMBH (DE) 1982-09-07 US claimed
EP-0998304-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING A BASIC DRUG, A CYCLODEXTRIN, A POLYMER AND AN ACID JANSSEN PHARMACEUTICA NV (BE) 2003-08-20 EP disclosed
US-20020150616-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLODEXTRINS JANSSEN PHARMACEUTICA N.V. (BE) 2002-10-17 US disclosed
EP-0998304-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLODEXTRINS JANSSEN PHARMACEUTICA N.V. (BE) 2000-05-10 EP disclosed
WO-1998055148-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLODEXTRINS JANSSEN PHARMACEUTICA N.V. (BE) 1998-12-10 WO disclosed
EP-0026876-B1 N-PHENOXYALKYLPIPERIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1983-02-16 EP disclosed
US-4348401-A ANTIHISTAMINIC, ANTIEDEMIC, ANTIPHLOGISTIC BOEHRINGER MANNHEIM GMBH (DE) 1982-09-07 US disclosed
US-4348401-A ANTIHISTAMINIC, ANTIEDEMIC, ANTIPHLOGISTIC BOEHRINGER MANNHEIM GMBH (DE) 1982-09-07 US disclosed
US-4348401-A ANTIHISTAMINIC, ANTIEDEMIC, ANTIPHLOGISTIC BOEHRINGER MANNHEIM GMBH (DE) 1982-09-07 US disclosed
EP-0026876-A1 N-phenoxyalkylpiperidine derivatives, processes for their preparation and medicaments containing these compounds Roche Diagnostics GmbH (DE) 1981-04-15 EP disclosed