Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141483 | 0.83 | SETD7 (0.42) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| SCHEMBL6990242 | 0.81 | HRH1 (0.42) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| SCHEMBL7136207 | 0.80 | SETD7 (0.59) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| SCHEMBL7142802 | 0.78 | HRH1 (0.41) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| SCHEMBL7136916 | 0.78 | SETD7 (0.38) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| Oxalic Acid SCHEMBL7138914 | 0.76 | KDM4E (0.40) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| Water SCHEMBL7165270 | 0.76 | NPC1 (0.38) | DRD2HTR2COPRK1DRD3TSHR | |
| SCHEMBL7139800 | 0.75 | PRMT5 (0.36) | HRH1DRD2CHRM2HTR1ACHRM1 | |
| SCHEMBL7135254 | 0.75 | SIGMAR1 (0.45) | ADRA1AKCNH2 | |
| SCHEMBL10409950 | 0.74 | SETD7 (0.56) | HRH1DRD2CHRM2HTR1ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675887-B1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-02 | — | — | EP | disclosed |
| EP-0675887-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994013671-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |