Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096281 | 0.91 | ACHE (0.41) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL7092866 | 0.77 | ACHE (0.42) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL7098081 | 0.75 | ACHE (0.41) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7140810 | 0.74 | ACHE (0.41) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL6421414 | 0.73 | ACHE (0.41) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL6421191 | 0.69 | ACHE (0.45) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL6423265 | 0.69 | MAPT (0.42) | MAPTLMNAPOLBTP53THRB | |
| SCHEMBL6421808 | 0.68 | ACHE (0.43) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL6420686 | 0.67 | ACHE (0.43) | ACHEHTR4MAPTKDM4EALDH1A1 | |
| SCHEMBL7093086 | 0.66 | F10 (0.40) | MAPTLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289953-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096304-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |