Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.53 |
| ▸ | EBP | Q15125 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8730444 | 0.91 | SIGMAR1 (0.63) | SIGMAR1EBPTMEM97 | |
| SCHEMBL1464842 | 0.82 | MAPK1 (0.55) | — | |
| SCHEMBL20482702 | 0.81 | CA2 (0.43) | SIGMAR1EBPTMEM97 | |
| SCHEMBL8354813 | 0.81 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4DSIGMAR1 | |
| SCHEMBL12040575 | 0.79 | EBP (0.67) | SIGMAR1EBPTMEM97 | |
| SCHEMBL7320184 | 0.79 | S1PR2 (0.51) | — | |
| SCHEMBL14722421 | 0.77 | PRSS1 (0.46) | SIGMAR1TMEM97 | |
| SCHEMBL10526510 | 0.77 | EBP (0.68) | SIGMAR1EBPTMEM97 | |
| SCHEMBL7119572 | 0.77 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4DSIGMAR1 | |
| SCHEMBL6355596 | 0.77 | MEN1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |
| EP-0934280-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998014432-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-09 | — | — | WO | disclosed |