Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.46 |
| ▸ | MIF | P14174 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143476 | 0.90 | CES1 (0.47) | MIFPKMCYP11B2CES1MAOA | |
| SCHEMBL7140651 | 0.81 | CES1 (0.47) | MIFPKMCYP11B2CES1MAOA | |
| SCHEMBL9286398 | 0.78 | SETD7 (0.55) | MAPK1ALDH1A1MAPTHSD17B10TP53 | |
| SCHEMBL7134438 | 0.74 | HPGD (0.46) | ALDH1A1HPGDSMN1; SMN2EED | |
| SCHEMBL1836197 | 0.73 | ALDH1A1 (0.62) | ALDH1A1MAPTHPGDNPC1RAB9A | |
| Oxalic Acid SCHEMBL1837116 | 0.69 | ALDH1A1 (0.59) | MAPK1ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7138437 | 0.69 | CES1 (0.47) | CYP19A1MIFPKMCYP11B2MAPK1 | |
| SCHEMBL4062450 | 0.68 | CES1 (0.61) | CYP19A1MIFPKMCYP11B2MAPK1 | |
| SCHEMBL4053483 | 0.68 | CES1 (0.61) | CYP19A1MIFPKMCYP11B2MAPK1 | |
| SCHEMBL29437756 | 0.68 | CES1 (0.90) | CYP19A1MIFPKMCYP11B2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675887-B1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-02 | — | — | EP | disclosed |
| EP-0675887-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994013671-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |