Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MIF | P14174 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142746 | 0.90 | CYP19A1 (0.46) | CES1HPGDMAOAMAPTTDP1 | |
| SCHEMBL7140651 | 0.84 | CES1 (0.47) | CES1MAOAKMT2AMAPTTDP1 | |
| SCHEMBL2792755 | 0.72 | MAPT (0.47) | HPGDKMT2ATSHRMAPTTDP1 | |
| SCHEMBL7138437 | 0.72 | CES1 (0.47) | CES1MAOAMAPTTDP1L3MBTL1 | |
| SCHEMBL7136783 | 0.71 | HPGD (0.58) | HPGDKMT2ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL44496 | 0.71 | CES1 (0.90) | CES1MAOAKMT2AMAPTTDP1 | |
| SCHEMBL29408351 | 0.71 | CES1 (0.90) | CES1MAOAKMT2AMAPTTDP1 | |
| SCHEMBL29437756 | 0.71 | CES1 (0.90) | CES1MAOAKMT2AMAPTTDP1 | |
| SCHEMBL2776723 | 0.71 | PARP1 (0.39) | HPGDKMT2ATSHRMAPTTDP1 | |
| SCHEMBL13185710 | 0.70 | KMT2A (0.40) | HPGDMAOAKMT2ATSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675887-B1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-02 | — | — | EP | disclosed |
| EP-0675887-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994013671-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |