Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047908 | 0.83 | CES1 (0.47) | MEN1KMT2ACRBNCREBBPPARP1 | |
| SCHEMBL11193913 | 0.83 | KMT2A (0.46) | MEN1KMT2ACRBNCREBBPPARP1 | |
| SCHEMBL7269697 | 0.83 | KMT2A (0.46) | MEN1KMT2ACRBNCREBBPPARP1 | |
| SCHEMBL9715259 | 0.83 | KMT2A (0.52) | MEN1KMT2ACRBNCREBBPPARP1 | |
| SCHEMBL10627797 | 0.80 | MEN1 (0.43) | MEN1KMT2ACRBNCREBBPBRD4 | |
| SCHEMBL31170855 | 0.80 | CRBN (0.44) | MEN1KMT2AGRIA1CACNG8CRBN | |
| SCHEMBL10654157 | 0.79 | MEN1 (0.43) | MEN1KMT2ACRBNCREBBPPARP1 | |
| SCHEMBL10627763 | 0.79 | MEN1 (0.43) | MEN1KMT2ACRBNCREBBPBRD4 | |
| SCHEMBL10964115 | 0.78 | DDB1 (0.42) | MEN1KMT2ACRBNDDB1LMNA | |
| SCHEMBL10365346 | 0.76 | PARP1 (0.44) | MEN1KMT2ACRBNPARP1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202977-B1 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-12-17 | — | — | EP | disclosed |
| EP-1202977-A2 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| US-6281353-B1 | EXPANSION WITH AN AMINECARBOXY COMPOUND THE CORRESPONDING3,1-BENZOXAZIN-2,4-DIONE COMPOUND | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000069835-A2 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-11-23 | — | — | WO | disclosed |
| US-4772696-A | CYCLIZATION USING ISONITRILE | A/S FERROSAN (DK) | 1988-09-20 | — | — | US | disclosed |
| US-4745112-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY ANTICONVULSANTS | A/S FERROSAN (DK) | 1988-05-17 | — | — | US | disclosed |
| US-4727153-A | NERVOUS SYSTEM DISORDERS | A/S FERROSAN (DK) | 1988-02-23 | — | — | US | disclosed |
| US-4670433-A | CARDIOVASCULAR DISORDERS | A/S FERROSAN (DK) | 1987-06-02 | — | — | US | disclosed |
| EP-0197282-A1 | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds | A/S FERROSAN (DK) | 1986-10-15 | — | — | EP | disclosed |
| US-4363762-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-12-14 | — | — | US | disclosed |
| US-4359420-A | HYPOTENSIVE AGENT, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1982-11-16 | — | — | US | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346030-A | ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346035-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346033-A | Thienodiazepinone and benzodiazepinone intermediates | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |