Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142836 | 0.83 | MEN1 (0.47) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL9715259 | 0.81 | KMT2A (0.52) | KMT2AMEN1HTTCRBNBRD4 | |
| SCHEMBL4047908 | 0.81 | CES1 (0.47) | KMT2AMEN1HTTCRBNBRD4 | |
| SCHEMBL11193913 | 0.81 | KMT2A (0.46) | KMT2AMEN1HTTCRBNBRD4 | |
| SCHEMBL10627763 | 0.81 | MEN1 (0.43) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL10627797 | 0.79 | MEN1 (0.43) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL10654157 | 0.78 | MEN1 (0.43) | KMT2AMEN1HTTCRBNBRD4 | |
| SCHEMBL10964115 | 0.77 | DDB1 (0.42) | KMT2AMEN1HTTCRBNLMNA | |
| SCHEMBL21257762 | 0.76 | HTT (0.46) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL7135878 | 0.76 | MEN1 (0.47) | KMT2AMEN1CRBNBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672666-B1 | Imidazodiazepins | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | EP | disclosed |
| US-5665718-A | ANXIOLYTIC, ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE, HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0672666-A2 | Imidazodiazepins | F. Hoffmann-La Roche AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| EP-0202441-B1 | OXADIAZOLYLIMIDAZOBENZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | A/S FERROSAN (DK) | 1988-11-17 | — | — | EP | disclosed |
| US-4745112-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY ANTICONVULSANTS | A/S FERROSAN (DK) | 1988-05-17 | — | — | US | disclosed |
| EP-0202441-A1 | Oxadiazolylimidazobenzodiazepines, process for their preparation and pharmaceutical compositions | A/S FERROSAN (DK) | 1986-11-26 | — | — | EP | disclosed |
| US-4363762-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-12-14 | — | — | US | disclosed |
| US-4359420-A | HYPOTENSIVE AGENT, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1982-11-16 | — | — | US | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346030-A | ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346035-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346033-A | Thienodiazepinone and benzodiazepinone intermediates | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |