Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142836 | 0.83 | MEN1 (0.47) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL4047908 | 0.81 | CES1 (0.47) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL11193913 | 0.81 | KMT2A (0.46) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL7269697 | 0.81 | KMT2A (0.46) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL30696906 | 0.81 | KMT2A (0.48) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL26677680 | 0.81 | KMT2A (0.48) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL10627797 | 0.79 | MEN1 (0.43) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL10627763 | 0.78 | MEN1 (0.43) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL10654157 | 0.78 | MEN1 (0.43) | KMT2AMEN1CRBNBRD4CREBBP | |
| SCHEMBL10964115 | 0.77 | DDB1 (0.42) | KMT2AMEN1CRBNPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353754-B1 | RADIOACTIVELY MARKED BENZODIAZEPIN DERIVATES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-02 | — | — | EP | disclosed |
| US-5096695-A | Diagnosis of brain disorders, cardiovascular diseases, epilepsy, psychosis | HOFFMANN-LAROCHE INC. (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0353754-A2 | Radioactively marked benzodiazepin derivates | F. HOFFMANN-LA ROCHE AG (CH) | 1990-02-07 | — | — | EP | disclosed |
| EP-0202441-B1 | OXADIAZOLYLIMIDAZOBENZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | A/S FERROSAN (DK) | 1988-11-17 | — | — | EP | disclosed |
| US-4745112-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY ANTICONVULSANTS | A/S FERROSAN (DK) | 1988-05-17 | — | — | US | disclosed |
| EP-0202441-A1 | Oxadiazolylimidazobenzodiazepines, process for their preparation and pharmaceutical compositions | A/S FERROSAN (DK) | 1986-11-26 | — | — | EP | disclosed |
| US-4352817-A | ANTIDOTE FOR TRANQUILLIZING EFFECTS OF 1,4-BENZODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0059389-A1 | Imidazodiazepines, process for their preparation and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | disclosed |