Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450256 | 0.86 | LSS (0.47) | LSSMGLLMAPTPOLBL3MBTL3 | |
| SCHEMBL7139780 | 0.86 | MGLL (0.46) | LSSMGLLMAPTPOLBL3MBTL3 | |
| SCHEMBL7142947 | 0.85 | LSS (0.39) | LSSMGLLKMT2AMEN1ALDH1A1 | |
| SCHEMBL6447923 | 0.79 | LSS (0.49) | LSSMGLLMAPTPOLBL3MBTL3 | |
| SCHEMBL5038775 | 0.78 | LSS (0.58) | LSSMGLLMAPTPOLBL3MBTL3 | |
| SCHEMBL5035561 | 0.78 | LSS (0.53) | LSSMGLLMAPTPOLBL3MBTL3 | |
| SCHEMBL7141682 | 0.78 | MGLL (0.44) | LSSMGLLMAPTPOLBKMT2A | |
| SCHEMBL5038807 | 0.78 | LSS (0.57) | LSSMGLLMAPTPOLBL3MBTL3 | |
| SCHEMBL5035557 | 0.78 | LSS (0.62) | LSSMGLLMAPTPOLBKMT2A | |
| SCHEMBL5035592 | 0.77 | LSS (0.61) | LSSMGLLMAPTPOLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-A1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020483-A1 | PIPERIDINE DERIVATIVES FOR USE 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |