Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145847 | 0.87 | LSS (0.45) | LSSGAATRPA1FAAHMGLL | |
| SCHEMBL6450140 | 0.87 | LSS (0.43) | LSSGAATRPA1CASP3MGLL | |
| SCHEMBL7143062 | 0.85 | LSS (0.46) | LSSMGLLMEN1ALDH1A1LMNA | |
| SCHEMBL6446568 | 0.80 | LSS (0.43) | LSSGAAMEN1ALDH1A1LMNA | |
| SCHEMBL6447732 | 0.80 | LSS (0.47) | LSSGAATRPA1CASP3MGLL | |
| SCHEMBL6450314 | 0.80 | LSS (0.44) | LSSGAAFAAH | |
| SCHEMBL6448108 | 0.80 | LSS (0.46) | LSSFAAHMEN1ALDH1A1LMNA | |
| SCHEMBL6449461 | 0.80 | LSS (0.47) | LSSMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL7142436 | 0.79 | LSS (0.46) | LSSGAAMGLL | |
| SCHEMBL6447639 | 0.79 | LSS (0.54) | LSSGAAMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-A1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020483-A1 | PIPERIDINE DERIVATIVES FOR USE 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |