Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120836 | 0.82 | TDP1 (0.39) | NPC1RAB9A | |
| SCHEMBL7143079 | 0.81 | CPT2 (0.47) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL18498477 | 0.80 | POLB (0.40) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21807985 | 0.80 | POLB (0.40) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7141674 | 0.78 | POLB (0.38) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7149001 | 0.77 | POLB (0.41) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL9044938 | 0.76 | POLB (0.39) | POLBNPC1SMN1; SMN2 | |
| SCHEMBL20315235 | 0.76 | PSEN1 (0.45) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL26477628 | 0.76 | PREP (0.57) | CTRB1PREP | |
| SCHEMBL7142747 | 0.75 | POLB (0.41) | POLBHTR2CCTRB1PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |