Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143079 | 0.79 | CPT2 (0.47) | POLBRAB9APSEN1PSEN2APH1B | |
| SCHEMBL9044938 | 0.79 | POLB (0.39) | POLBCYP2C9NPC1SMN1; SMN2 | |
| SCHEMBL7143386 | 0.78 | POLB (0.41) | POLBRAB9APSEN1PSEN2APH1B | |
| SCHEMBL7142747 | 0.76 | POLB (0.41) | POLBTSHRCTRB1PREP | |
| SCHEMBL7138322 | 0.76 | POLB (0.42) | POLBRAB9ACTRB1NPC1SMN1; SMN2 | |
| SCHEMBL9041784 | 0.75 | CYP3A4 (0.56) | POLBRAB9ACYP3A4MAPTCYP2C9 | |
| SCHEMBL7143663 | 0.74 | CYP3A4 (0.44) | POLBRAB9ACYP3A4MAPTCYP2C9 | |
| SCHEMBL7149001 | 0.74 | POLB (0.41) | POLBRAB9ATSHRPSEN1PSEN2 | |
| SCHEMBL7141868 | 0.74 | DCUN1D1 (0.41) | POLBRAB9AOPRM1CTRB1NPC1 | |
| SCHEMBL7150573 | 0.74 | OPRM1 (0.54) | OPRM1OPRK1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |