Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 11/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252261 | 0.84 | L3MBTL1 (0.43) | GRIK1GRIA2L3MBTL1TSHRALDH1A1 | |
| SCHEMBL5506318 | 0.82 | CTSC (0.42) | TSHRALDH1A1CYP2D6 | |
| SCHEMBL28679839 | 0.82 | CTSC (0.42) | TSHRALDH1A1CYP2D6 | |
| SCHEMBL20446605 | 0.82 | CA1 (0.42) | GRIK1GRIA2L3MBTL1TSHRALDH1A1 | |
| SCHEMBL6250751 | 0.80 | TSHR (0.43) | TSHRALDH1A1CYP2D6 | |
| Proline SCHEMBL3060990 | 0.78 | CYP2D6 (0.43) | L3MBTL1TSHRALDH1A1CYP2D6 | |
| Proline SCHEMBL3060992 | 0.78 | CYP2D6 (0.43) | L3MBTL1TSHRALDH1A1CYP2D6 | |
| D-Proline SCHEMBL3803838 | 0.78 | CYP2D6 (0.43) | L3MBTL1TSHRALDH1A1CYP2D6 | |
| SCHEMBL7425043 | 0.78 | L3MBTL1 (0.57) | GRIK1GRIA2L3MBTL1CYP2D6 | |
| SCHEMBL7331455 | 0.78 | L3MBTL1 (0.57) | GRIK1GRIA2L3MBTL1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368032-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2003024453-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-03-27 | — | — | WO | claimed |