SCHEMBL7143579

SCHEMBL7143579

Nc1ccc(-c2ccc(-c3ccccc3Cl)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.62
MAOB P27338 2/20 0.60
CYP3A4 P08684 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
TAAR1 Q96RJ0 2/20 0.54
HSD17B10 Q99714 2/20 0.54
ALDH1A1 P00352 3/20 0.50
TP53 P04637 2/20 0.50
PLA2G7 Q13093 1/20 0.50
USP7 Q93009 1/20 0.47
BACE1 P56817 1/20 0.47
JAK2 O60674 1/20 0.46
JAK1 P23458 1/20 0.46
TYK2 P29597 1/20 0.46
JAK3 P52333 1/20 0.46
SCN9A Q15858 1/20 0.44
TSHR P16473 1/20 0.42
DPP4 P27487 1/20 0.42
KDM4E B2RXH2 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1337085 0.98 CYP2A6 (0.65) CYP2A6MAOBCYP3A4TDP1TAAR1
SCHEMBL6436152 0.83 CYP2A6 (0.90) CYP2A6MAOBCYP3A4HSD17B10ALDH1A1
SCHEMBL29118206 0.83 HSD17B10 (0.68) CYP3A4TDP1TAAR1HSD17B10ALDH1A1
SCHEMBL30208583 0.83 HSD17B10 (0.68) CYP3A4TDP1TAAR1HSD17B10ALDH1A1
SCHEMBL8176171 0.82 PLA2G7 (0.61) CYP2A6MAOBCYP3A4TDP1TAAR1
Biphenyl-4-Amine SCHEMBL29046424 0.81 CYP3A4 (0.75) CYP2A6CYP3A4TDP1TAAR1HSD17B10
SCHEMBL2994341 0.80 CNR2 (0.50) CYP2A6MAOBCYP3A4TDP1TAAR1
SCHEMBL9246341 0.80 HSD17B10 (0.63) CYP3A4TDP1TAAR1HSD17B10ALDH1A1
SCHEMBL8677116 0.79 MAOB (0.45) CYP2A6MAOBCYP3A4TDP1TAAR1
Methane SCHEMBL29157416 0.78 CNR2 (0.49) CYP2A6MAOBCYP3A4TDP1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789577-B1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORP (US) 2003-03-12 EP disclosed
EP-0671928-B1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORP (US) 2002-11-27 EP disclosed
EP-1258492-A1 N-substituted oligomers and methods for their synthesis, e.g. polyglycine bearing nucleic acid bases CHIRON CORPORATION (US) 2002-11-20 EP disclosed
US-5977301-A AUTOMATED AND EFFICIENT SYNTHESIS BY REACTING SOLID SUPPORT BOUND AMINE WITH AN ACYLATING SUBMONOMER TO PRODUCE A SOLID SUPPORT-BOUND AMIDE WHICH CAN BE FURTHER REACTED; ONLY REACTIVE SIDE CHAINS NEED PROTECTED CHIRON CORPORATION (US) 1999-11-02 US disclosed
US-5877278-A SOLID PHASE SYNTHESIS USING TWO SUBMONOMERS-AN ACYLATING AGENT, E.G. A HALOACETIC ACID, AND A PRIMARY AMINE; CYCLIZATION TO PRODUCE MIMETICS OF DRUGS; ELIMINATION OF THE NECESSITY OF PROTECTION GROUPS CHIRON CORPORATION (US) 1999-03-02 US disclosed
US-5831005-A ACYLATION, NUCLEOPHILIC DISPLACEMENT CYCLES CHIRON CORPORATION (US) 1998-11-03 US disclosed
EP-0789577-A4 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORP (US) 1998-07-22 EP disclosed
EP-0789577-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1997-08-20 EP disclosed
WO-1996040202-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1996-12-19 WO disclosed
US-5480871-A TREATMENT OF BENIGN PROSTATIC HYPERPLASIA CHIRON CORPORATION (US) 1996-01-02 US disclosed
US-5447916-A Hypotensive agents CHIRON CORPORATION (US) 1995-09-05 US disclosed
WO-1995004072-A1 PEPTOID ALPHA-1 ADRENERGIC RECEPTOR LIGANDS CHIRON CORPORATION (US) 1995-02-09 WO disclosed