Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222423 | 0.85 | HDAC8 (0.50) | ESR2CYP2C9HDAC8HDAC6HDAC1 | |
| SCHEMBL2941705 | 0.83 | SMN1; SMN2 (0.59) | ESR2HDAC8HDAC6HDAC1RAB9A | |
| SCHEMBL469036 | 0.81 | HDAC8 (0.61) | CYP2C9HDAC8HDAC6HDAC1RAB9A | |
| SCHEMBL6139859 | 0.80 | TRPA1 (0.46) | ESR2HDAC8HDAC6HDAC1RAB9A | |
| SCHEMBL15081033 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6HDAC1RAB9ANPC1 | |
| SCHEMBL13445251 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6HDAC1RAB9ANPC1 | |
| SCHEMBL12337677 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6HDAC1RAB9ANPC1 | |
| SCHEMBL6822864 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6HDAC1RAB9ANPC1 | |
| SCHEMBL6822733 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6HDAC1RAB9ANPC1 | |
| SCHEMBL14231550 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6HDAC1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | disclosed |
| EP-1192122-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076953-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2000-12-21 | — | — | WO | disclosed |