Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.53 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967133 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL15905969 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL14231550 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL15081033 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL12337677 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL6822733 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL28595922 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL6822864 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL13445251 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL11136357 | 0.93 | HDAC8 (0.54) | HDAC8HDAC6HDAC1HAO1DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020790-B | Preparation method of 4-naphthenic acetophenone derivative | 苏州大学 | 2021-07-27 | — | — | CN | disclosed |
| US-9932573-B2 | Labeled enzyme compositions, methods and systems | Life Technologies Corporation (US) | 2018-04-03 | — | — | US | disclosed |
| US-9567629-B2 | Labeled enzyme compositions, methods and systems | Life Technologies Corporation (US) | 2017-02-14 | — | — | US | disclosed |
| US-9139456-B2 | Chelating compounds and immobilized tethered chelators | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2015-09-22 | — | — | US | disclosed |
| US-20120061325-A1 | CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2012-03-15 | — | — | US | disclosed |
| US-8066883-B2 | Removing aluminum from solution using chelating compounds and immobilized tethered chelators | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110168636-A1 | CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2011-07-14 | — | — | US | disclosed |
| US-7932326-B2 | Chelating compounds and immobilized tethered chelators | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090261043-A1 | CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2009-10-22 | — | — | US | disclosed |
| US-6737438-B2 | EFFECTIVE IN MULTIDRUG RESISTANT MICE | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-05-18 | — | — | US | disclosed |
| US-20040053991-A1 | Substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof | COUNCIL SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-03-18 | — | — | US | disclosed |
| US-4016214-A | Preparation of ethynylbenzenes | WILLIAM H. RORER, INC. (US) | 1977-04-05 | — | — | US | disclosed |
| US-3952067-A | Ethynylbenzenes | WILLIAM H. RORER, INC. (US) | 1976-04-20 | — | — | US | disclosed |
| US-3950427-A | ANTIINFLAMMATORY, ANTIPYRETIC | BOEHRINGER INGELHEIM GMBH (DT) | 1976-04-13 | — | — | US | disclosed |
| US-3944589-A | α-Cycloalkenylphenyl-fatty acid nitriles | CIBA-GEIGY CORPORATION (US) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053991-A1 | Substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof | DHPS, TBXAS1, ABCC1 | HDAC8 3105/4885HDAC6 4657/4885HDAC1 3137/4885 |
| US-20120061325-A1 | CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS | BTD, TTPA, SLC39A7 | HDAC8 124/4885HDAC6 523/4885HDAC1 531/4885 |
| US-20090261043-A1 | CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS | BTD, SLC30A7, SLC39A7 | HDAC8 462/4885HDAC6 1443/4885HDAC1 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.