Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139747 | 1.00 | UCHL1 (0.47) | UCHL1JAK2JAK1CYP2C9CYP2C19 | |
| SCHEMBL7142421 | 0.88 | ALDH1A1 (0.46) | JAK2JAK1CYP2C9CYP2C19MAPK14 | |
| SCHEMBL6691355 | 0.88 | ALDH1A1 (0.46) | JAK2JAK1CYP2C9CYP2C19MAPK14 | |
| SCHEMBL6684723 | 0.88 | CYP2C9 (0.50) | CYP2C9CYP2C19MAPK14ALDH1A1L3MBTL1 | |
| SCHEMBL6692099 | 0.88 | CYP2C9 (0.50) | CYP2C9CYP2C19MAPK14ALDH1A1L3MBTL1 | |
| SCHEMBL6661762 | 0.83 | HSD17B10 (0.63) | UCHL1CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL6655904 | 0.83 | HSD17B10 (0.63) | UCHL1CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL6663316 | 0.83 | HSD17B10 (0.63) | UCHL1CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL6692481 | 0.81 | CYP2C9 (0.50) | CYP2C9CYP2C19MAPK14ALDH1A1L3MBTL1 | |
| SCHEMBL6692489 | 0.81 | CYP2C9 (0.50) | CYP2C9CYP2C19MAPK14ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030191110-A1 | Modulators of the cholesterol biosynthetic pathway | VERTEX PHARMACEUTICALS, INCORPORATED | 2003-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191110-A1 | Modulators of the cholesterol biosynthetic pathway | SREBF2, SREBF1, CYP46A1 | UCHL1 4520/4885JAK2 4406/4885JAK1 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.