Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028118 | 0.74 | TDP1 (0.40) | — | |
| SCHEMBL5094808 | 0.74 | GAA (0.52) | MKNK1MKNK2JAK2JAK3 | |
| SCHEMBL4398202 | 0.73 | MKNK1 (0.53) | MKNK1MKNK2 | |
| SCHEMBL7143770 | 0.72 | MKNK1 (0.45) | MKNK1MKNK2 | |
| SCHEMBL5100325 | 0.69 | MKNK2 (0.75) | MKNK1MKNK2 | |
| SCHEMBL5095181 | 0.68 | MKNK1 (0.42) | MKNK1MKNK2 | |
| SCHEMBL7143772 | 0.68 | GSK3B (0.41) | MKNK1MKNK2JAK2JAK3 | |
| SCHEMBL5091775 | 0.65 | MAPT (0.43) | MKNK1MKNK2 | |
| SCHEMBL5089535 | 0.64 | MKNK1 (0.50) | MKNK1MKNK2 | |
| SCHEMBL5093386 | 0.64 | MKNK1 (0.53) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |