Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | STAT1 | P42224 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398205 | 0.76 | GSK3B (0.58) | MKNK1MKNK2GSK3BSMN1; SMN2ALDH1A1 | |
| SCHEMBL7143772 | 0.74 | GSK3B (0.41) | MKNK1MKNK2GSK3BPKMSMN1; SMN2 | |
| SCHEMBL5095187 | 0.73 | MKNK1 (0.41) | MKNK1MKNK2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7143768 | 0.72 | MKNK1 (0.43) | MKNK1MKNK2 | |
| SCHEMBL5100325 | 0.71 | MKNK2 (0.75) | MKNK1MKNK2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5100332 | 0.69 | MMP2 (0.54) | MKNK1MKNK2GSK3BSMN1; SMN2L3MBTL1 | |
| SCHEMBL5094808 | 0.69 | GAA (0.52) | MKNK1MKNK2MAPTKDM4E | |
| SCHEMBL5089535 | 0.66 | MKNK1 (0.50) | MKNK1MKNK2GSK3BSMN1; SMN2 | |
| SCHEMBL5093386 | 0.66 | MKNK1 (0.53) | MKNK1MKNK2GSK3BSMN1; SMN2ALDH1A1 | |
| SCHEMBL5099347 | 0.66 | GSK3B (0.50) | MKNK1MKNK2GSK3BSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |