Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094808 | 0.81 | GAA (0.52) | JAK2MKNK1MKNK2MAPTJAK3 | |
| SCHEMBL4398205 | 0.80 | GSK3B (0.58) | GSK3BMKNK1MKNK2MAPTSMN1; SMN2 | |
| SCHEMBL5100332 | 0.80 | MMP2 (0.54) | GSK3BMKNK1MKNK2MAPTL3MBTL1 | |
| SCHEMBL5095173 | 0.80 | POLB (0.45) | NPC1RAB9A | |
| SCHEMBL5089385 | 0.74 | NAMPT (0.44) | GSK3BMKNK1MKNK2 | |
| SCHEMBL7143770 | 0.74 | MKNK1 (0.45) | GSK3BMKNK1MKNK2MAPTL3MBTL1 | |
| SCHEMBL5099347 | 0.71 | GSK3B (0.50) | GSK3BMKNK1MKNK2MAPTSMN1; SMN2 | |
| SCHEMBL5100147 | 0.71 | POLB (0.48) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL5093881 | 0.70 | POLB (0.49) | GSK3BMAPTL3MBTL1SMN1; SMN2THRB | |
| SCHEMBL5093386 | 0.70 | MKNK1 (0.53) | GSK3BMKNK1MKNK2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |