Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5998652 | 0.79 | GRIN2D (0.52) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL7143962 | 0.72 | GRIN2D (0.46) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL10979626 | 0.70 | TSHR (0.59) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL31093995 | 0.68 | ALDH1A1 (0.54) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL11299940 | 0.68 | ALDH1A1 (0.54) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL11029357 | 0.66 | TSHR (0.52) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL8645578 | 0.66 | TSHR (0.59) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL5998202 | 0.65 | KDM4E (0.44) | ALDH1A1IMPDH2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6816439 | 0.65 | ALDH1A1 (0.50) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL15778487 | 0.65 | TDP1 (0.45) | TSHRALDH1A1TDP1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003092679-A1 | PREPARATION OF PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA, INC. (US) | 2003-11-13 | — | — | WO | disclosed |