Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.56 |
| ▸ | MEN1 | O00255 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28775114 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL3902453 | 0.86 | KMT2A (0.73) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL2955716 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL13836493 | 0.84 | ALDH1A1 (0.61) | SMN1; SMN2KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL2200367 | 0.82 | ALDH1A1 (0.62) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL13265910 | 0.80 | MAPT (0.58) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL1248559 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL13265912 | 0.79 | MAPT (0.65) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL10549815 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| Acetanilide SCHEMBL27366940 | 0.78 | KMT2A (0.69) | SMN1; SMN2KMT2AMEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |