Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003260 | 0.83 | SIGMAR1 (0.68) | SIGMAR1CHRM2CHRM1CHRM3KMT2A | |
| SCHEMBL5402061 | 0.81 | SIGMAR1 (0.68) | SIGMAR1CHRM2CHRM1CHRM3KMT2A | |
| SCHEMBL7268908 | 0.79 | SIGMAR1 (0.79) | SIGMAR1POLB | |
| SCHEMBL3164487 | 0.79 | SIGMAR1 (0.74) | SIGMAR1KMT2AMEN1DRD4DRD2 | |
| SCHEMBL5230894 | 0.79 | SIGMAR1 (0.74) | SIGMAR1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL2425554 | 0.79 | SIGMAR1 (0.78) | SIGMAR1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL17294676 | 0.79 | CHRM3 (0.72) | SIGMAR1CHRM2CHRM1CHRM3KMT2A | |
| Hydrochloric Acid SCHEMBL29640479 | 0.78 | SIGMAR1 (0.77) | SIGMAR1POLB | |
| Hydrochloric Acid SCHEMBL21410212 | 0.77 | SIGMAR1 (0.76) | SIGMAR1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL13102940 | 0.77 | DRD4 (0.78) | SIGMAR1KMT2ADRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |