Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 17/20 | 0.79 |
| ▸ | CCR8 | P51685 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29640479 | 0.99 | SIGMAR1 (0.77) | SIGMAR1CCR8POLBL3MBTL1 | |
| SCHEMBL9852459 | 0.89 | SIGMAR1 (0.75) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL4730146 | 0.89 | SIGMAR1 (0.75) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL5862113 | 0.88 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL6750438 | 0.87 | SIGMAR1 (0.77) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL12642482 | 0.87 | SIGMAR1 (0.72) | SIGMAR1CCR8 | |
| SCHEMBL5124505 | 0.87 | SIGMAR1 (0.81) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL29640480 | 0.87 | SIGMAR1 (0.81) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL3075354 | 0.87 | SIGMAR1 (0.81) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL4592787 | 0.86 | SIGMAR1 (0.73) | SIGMAR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183232-B1 | SUBSTITUTED 1-ARYLETHYL-4-ACYLAMINOPIPERIDINE DERIVATIVES AS OPIOID/ALPHA-ADRENORECEPTOR MODULATORS AND METHOD OF THEIR PREPARATION | UNIV ARIZONA (US) | 2023-05-03 | — | — | EP | claimed |
| WO-2023133135-A2 | SMALL MOLECULE ADRENORECEPTOR ANTAGONISTS AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2023-07-13 | — | — | WO | disclosed |
| EP-3183232-B1 | SUBSTITUTED 1-ARYLETHYL-4-ACYLAMINOPIPERIDINE DERIVATIVES AS OPIOID/ALPHA-ADRENORECEPTOR MODULATORS AND METHOD OF THEIR PREPARATION | UNIV ARIZONA (US) | 2023-05-03 | — | — | EP | disclosed |
| EP-3183232-B1 | SUBSTITUTED 1-ARYLETHYL-4-ACYLAMINOPIPERIDINE DERIVATIVES AS OPIOID/ALPHA-ADRENORECEPTOR MODULATORS AND METHOD OF THEIR PREPARATION | UNIV ARIZONA (US) | 2023-05-03 | — | — | EP | disclosed |
| US-11440885-B2 | Substituted 1-arylalkyl-4-acylaminopiperidine compounds and methods of producing and using the same | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERISTY OF ARIZONA (US) | 2022-09-13 | — | — | US | disclosed |
| EP-4010341-A1 | TRKB POSITIVE ALLOSTERIC MODULATORS | Université de Strasbourg (FR) | 2022-06-15 | — | — | EP | disclosed |
| US-20200222380-A1 | Substituted 1-Arylalkyl-4-Acylaminopiperidine Compounds and Methods of Producing and Using the Same | ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA, A BODY CORPORATE (US) | 2020-07-16 | — | — | US | disclosed |
| US-10617681-B2 | 1-arylalkyl-4-acylaminopiperidine compounds | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-04-14 | — | — | US | disclosed |
| US-20190134018-A1 | 1-ARYLALKYL-4-ACYLAMINOPIPERIDINE COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-05-09 | — | — | US | disclosed |
| US-20190055217-A1 | PIPERIDINYLALKYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-02-21 | — | — | US | disclosed |
| WO-2016029218-A1 | SUBSTITUTED 1-ARYLETHYL-4-ACYLAMINOPIPERIDINE DERIVATIVES AS OPIOID/ALPHA-ADRENORECEPTOR MODULATORS AND METHOD OF THEIR PREPARATION | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2016-02-25 | — | — | WO | disclosed |
| WO-2016029218-A1 | SUBSTITUTED 1-ARYLETHYL-4-ACYLAMINOPIPERIDINE DERIVATIVES AS OPIOID/ALPHA-ADRENORECEPTOR MODULATORS AND METHOD OF THEIR PREPARATION | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2016-02-25 | — | — | WO | disclosed |
| US-7629468-B2 | Neuroprotectants, analgesics or anticonvulsants | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7629468-B2 | Neuroprotectants, analgesics or anticonvulsants | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7517517-B2 | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-14 | — | — | US | disclosed |
| US-7517517-B2 | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-14 | — | — | US | disclosed |
| WO-2003082350-A2 | RADIOLABELLED QUINOLINE AND QUINOLINONE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-09 | — | — | WO | disclosed |
| US-5214055-A | Analgesics, psychological disorders, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5189045-A | Antiserotonine agent | ADIR ET COMPAGNIE (FR) | 1993-02-23 | — | — | US | disclosed |
| EP-0457686-A1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190055217-A1 | PIPERIDINYLALKYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRD1, OPRK1, OPRM1 | SIGMAR1 5/4885CCR8 754/4885POLB 657/4885 |
| US-20200222380-A1 | Substituted 1-Arylalkyl-4-Acylaminopiperidine Compounds and Methods of Producing and Using the Same | HRH4, OPRL1, OPRK1 | SIGMAR1 70/4885CCR8 114/4885POLB 3955/4885 |
| US-20190134018-A1 | 1-ARYLALKYL-4-ACYLAMINOPIPERIDINE COMPOUNDS | NR5A2, NR0B1, NR4A3 | SIGMAR1 294/4885CCR8 568/4885POLB 4249/4885 |
| US-11440885-B2 | Substituted 1-arylalkyl-4-acylaminopiperidine compounds and methods of producing and using the same | HRH4, OPRL1, OPRK1 | SIGMAR1 70/4885CCR8 114/4885POLB 3955/4885 |
| US-10617681-B2 | 1-arylalkyl-4-acylaminopiperidine compounds | NR5A2, NR0B1, NR4A3 | SIGMAR1 294/4885CCR8 568/4885POLB 4249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.