SCHEMBL7144398

SCHEMBL7144398

Cc1ccccc1C(=O)c1ccccc1C(=O)Cl

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
KMT2A Q03164 1/20 0.50
MAPK13 O15264 4/20 0.47
MAPK12 P53778 4/20 0.47
MAPK11 Q15759 4/20 0.47
MAPK14 Q16539 4/20 0.47
ALDH1A1 P00352 3/20 0.47
ALOX15 P16050 1/20 0.47
HPGD P15428 1/20 0.44
ERCC5 P28715 1/20 0.43
FEN1 P39748 1/20 0.43
ENPP3 O14638 1/20 0.42
ALPL P05186 1/20 0.42
XIAP P98170 1/20 0.42
BCHE P06276 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10669335 0.89 CYP3A4 (0.59) CYP3A4CYP2C9KMT2AMAPK13MAPK12
SCHEMBL29677294 0.87 ALDH1A1 (0.54) KMT2AALDH1A1ALOX15HPGDERCC5
SCHEMBL93382 0.87 ALDH1A1 (0.54) KMT2AALDH1A1ALOX15HPGDERCC5
SCHEMBL29387256 0.87 CYP3A4 (0.55) CYP3A4CYP2C9KMT2AMAPK13MAPK12
SCHEMBL333141 0.87 CYP3A4 (0.55) CYP3A4CYP2C9KMT2AMAPK13MAPK12
SCHEMBL9375700 0.87 ALDH1A1 (0.58) CYP3A4CYP2C9KMT2AALDH1A1ALOX15
Hydrochloric Acid SCHEMBL8173416 0.85 MAPK13 (0.42) CYP3A4CYP2C9KMT2AMAPK13MAPK12
Ammonia Solution, Strong SCHEMBL27608787 0.85 ALDH1A1 (0.52) KMT2AALDH1A1ALOX15HPGDERCC5
SCHEMBL8799814 0.83 MAPK13 (0.44) CYP3A4CYP2C9KMT2AMAPK13MAPK12
SCHEMBL357669 0.81 CYP3A4 (0.72) CYP3A4CYP2C9KMT2AALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1289939-A1 PHENYLGLYCINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2003-03-12 EP disclosed
WO-2001090051-A1 PHENYLGLYCINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-11-29 WO disclosed
US-5117057-A Insecticidal N' substituted-N-N'-disubstituted-hydrazines ROHM AND HAAS COMPANY (US) 1992-05-26 US disclosed