SCHEMBL9375700

SCHEMBL9375700

O=C(Cl)c1ccccc1C(=O)c1ccccc1C(=O)Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.58
ALOX15 P16050 2/20 0.58
AKR1C3 P42330 3/20 0.46
TP53 P04637 1/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
TSHR P16473 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
CDC25B P30305 3/20 0.43
NR4A1 P22736 1/20 0.43
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
KMT2A Q03164 1/20 0.41
CDC25A P30304 1/20 0.40
HSD17B10 Q99714 1/20 0.40
ATM Q13315 1/20 0.40
PRNP P04156 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL422 0.91 ALDH1A1 (0.67) ALDH1A1ALOX15AKR1C3TP53GAA
SCHEMBL9712554 0.89 CES2 (0.58) ALDH1A1ALOX15GAACES2CES1
SCHEMBL28422933 0.88 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3TP53GAA
Hydrochloric Acid SCHEMBL28325289 0.88 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3TP53GAA
SCHEMBL9712558 0.87 ALDH1A1 (0.76) ALDH1A1ALOX15GAAMAPTSMN1; SMN2
SCHEMBL7144398 0.87 CYP3A4 (0.50) ALDH1A1ALOX15CYP3A4CYP2C9KMT2A
SCHEMBL9712553 0.87 PRNP (0.49) ALDH1A1ALOX15AKR1C3SMN1; SMN2KMT2A
SCHEMBL31672209 0.85 AKR1C3 (0.68) ALDH1A1ALOX15AKR1C3GAAMAPT
SCHEMBL78316 0.85 AKR1C3 (0.68) ALDH1A1ALOX15AKR1C3GAAMAPT
Cyclohexane SCHEMBL28429706 0.83 ALDH1A1 (0.58) ALDH1A1ALOX15MAPTTSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0359341-B1 1,6-diazaspiro[4,4]nonane-2,7-dione derivatives SHELL INT RESEARCH (NL) 1994-02-16 EP disclosed
US-5164470-A Polymer compositions SHELL OIL COMPANY (US) 1992-11-17 US disclosed
US-5149823-A Sulfonamide substituted spirodilactams SHELL OIL COMPANY (US) 1992-09-22 US disclosed
US-5145910-A Ketocarboxylated polymers SHELL OIL COMPANY (US) 1992-09-08 US disclosed
US-5112938-A CYANO- AND CARBOXY-SUBSTITUTED SPIRODILACTAMS SHELL OIL COMPANY (US) 1992-05-12 US disclosed
US-5103001-A SPIRODILACTAMS SHELL OIL COMPANY (US) 1992-04-07 US disclosed
US-5093495-A Benzoheterocyclic compounds SHELL OIL COMPANY (US) 1992-03-03 US disclosed
US-5093465-A Polyamide containing spirodilactam moieties SHELL OIL COMPANY (US) 1992-03-03 US disclosed
US-5093500-A Spirodilactam bisimides SHELL OIL COMPANY (US) 1992-03-03 US disclosed
US-5093499-A Spirodilactam derivatives SHELL OIL COMPANY (US) 1992-03-03 US disclosed
US-4940801-A Spirodilactam derivatives SHELL OIL COMPANY (US) 1990-07-10 US disclosed
US-4939251-A Novel spirolactones SHELL OIL COMPANY (US) 1990-07-03 US disclosed
US-4939270-A Spirodilactam diamines SHELL OIL COMPANY (US) 1990-07-03 US disclosed
US-4927906-A Novel polyamideimide polymers SHELL OIL COMPANY (US) 1990-05-22 US disclosed
US-4924014-A Process for the preparation of halogen-containing aromatic compounds HOECHST AKTIENGESELLSCHAFT (DE) 1990-05-08 US disclosed
US-4914176-A Poly(heterocyclic) polymers SHELL OIL COMPANY (US) 1990-04-03 US disclosed
EP-0359341-A2 1,6-diazaspiro[4,4]nonane-2,7-dione derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-03-21 EP disclosed
US-4885351-A Spirodilactam derivatives SHELL OIL COMPANY (US) 1989-12-05 US disclosed
US-4785074-A PROTECTIVE COATINGS, RELIEF IMAGES CIBA-GEIGY CORPORATION (US) 1988-11-15 US disclosed
US-4694061-A POLYAMIDE(IMIDE)S CONTAINING BENZOPHENONE (DI-ORTRI)CARBOXYLIC ACID CIBA-GEIGY CORPORATION (US) 1987-09-15 US disclosed