Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.58 |
| ▸ | FAAH | O00519 | 5/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5997826 | 0.91 | MAPK14 (0.57) | MAPK14FAAHMAPK13MAPK12MAPK11 | |
| SCHEMBL4347807 | 0.86 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1127850 | 0.84 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5998468 | 0.84 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7144416 | 0.82 | MAPK14 (0.75) | MAPK14FAAHMAPK13MAPK12MAPK11 | |
| SCHEMBL13670475 | 0.79 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5903491 | 0.78 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7162537 | 0.77 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL8102854 | 0.77 | MAPK14 (0.47) | MAPK14FAAHMAPK13MAPK12MAPK11 | |
| SCHEMBL7139249 | 0.76 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028954-B1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO MCNEIL PHARM INC (US) | 2003-07-02 | — | — | EP | claimed |
| EP-1028954-A1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-08-23 | — | — | EP | claimed |
| WO-1998047892-A1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO-MCNEIL CORPORATION, INC. (US) | 1998-10-29 | — | — | WO | claimed |