Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16573706 | 0.85 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11NPSR1 | |
| SCHEMBL8098012 | 0.85 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11NPSR1 | |
| SCHEMBL8129355 | 0.83 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11FAAH | |
| SCHEMBL14549160 | 0.77 | POLB (0.38) | MAPK14NPSR1FAAH | |
| SCHEMBL7144420 | 0.77 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11SMN1; SMN2 | |
| SCHEMBL7144416 | 0.77 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11SMN1; SMN2 | |
| SCHEMBL5903491 | 0.75 | MAPK14 (0.68) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL7162537 | 0.74 | MAPK14 (0.67) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL27489999 | 0.73 | MAPK14 (0.58) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL13670475 | 0.73 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994858-A1 | 2-SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-04-26 | — | — | EP | disclosed |
| US-6040320-A | ANTIINFLAMMATORY AGENT FOR TREATING DISEASES ASSOCIATED WITH OVERPRODUCTION OF INFLAMMATORY CYTOKINES, SUCH AS RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISEASE, SEPTIC SHOCK, OSTEOPOROSIS, AND OSTEOARTHRITIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| WO-1999003837-A1 | 2-SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-01-28 | — | — | WO | disclosed |