Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.53 |
| ▸ | GAB1 | Q13480 | 5/20 | 0.53 |
| ▸ | IRS1 | P35568 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610154 | 0.87 | AKT1 (0.55) | AKT1GAB1IRS1ALDH1A1FFAR4 | |
| SCHEMBL3256711 | 0.79 | AKT1 (0.56) | AKT1GAB1IRS1ALDH1A1FFAR4 | |
| SCHEMBL3256918 | 0.77 | AKT1 (0.47) | AKT1GAB1IRS1ALDH1A1FFAR4 | |
| SCHEMBL3610724 | 0.76 | ALDH1A1 (0.59) | AKT1GAB1IRS1ALDH1A1PDPK1 | |
| SCHEMBL5911686 | 0.73 | ALDH1A1 (0.73) | AKT1ALDH1A1FFAR4 | |
| SCHEMBL31681345 | 0.72 | ALDH1A1 (0.63) | ALDH1A1FFAR4 | |
| SCHEMBL3609991 | 0.71 | KMT2A (0.51) | ALDH1A1 | |
| SCHEMBL3618698 | 0.70 | KMT2A (0.56) | ALDH1A1 | |
| SCHEMBL5912136 | 0.70 | ALDH1A1 (0.79) | AKT1GAB1IRS1ALDH1A1 | |
| SCHEMBL7093105 | 0.70 | AKT1 (0.47) | AKT1GAB1IRS1ALDH1A1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283831-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | claimed |
| WO-2001090090-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | claimed |