Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | DRD3 | P35462 | 5/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008525 | 0.79 | DRD2 (0.39) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL1430677 | 0.75 | KDM4E (0.40) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL7002384 | 0.75 | KDM4E (0.42) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL6619103 | 0.74 | DRD2 (0.38) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL7006187 | 0.73 | DRD2 (0.37) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL7004475 | 0.72 | DRD2 (0.39) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL6617602 | 0.72 | KDM4E (0.39) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL7001788 | 0.71 | DRD2 (0.38) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL1243656 | 0.71 | ALDH1A1 (0.45) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL6619743 | 0.70 | KDM4E (0.36) | DRD2DRD3DRD4HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123936-B1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1123936-A1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |