Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7146324 | 0.99 | HTR1A (0.69) | HTR1ASLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL8011275 | 0.82 | HTR1A (1.00) | HTR1ADRD2ADRA1ADRD3 | |
| SCHEMBL977564 | 0.81 | DRD2 (0.58) | HTR1ADRD2ADRA1ADRD3MAPT | |
| SCHEMBL11784383 | 0.81 | SLC6A2 (0.59) | HTR1ASLC6A2SLC6A4DRD2ADRA1A | |
| Bromide SCHEMBL7207014 | 0.79 | DRD2 (0.67) | HTR1ASLC6A4DRD2ADRA1ADRD3 | |
| SCHEMBL7212266 | 0.78 | HTR1A (0.64) | HTR1ASLC6A2SLC6A4DRD2ADRA1A | |
| Bromide SCHEMBL7212285 | 0.77 | HTR1A (0.62) | HTR1ASLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL7888415 | 0.76 | GAA (0.54) | HTR1ASLC6A2SLC6A4LMNAMAPT | |
| SCHEMBL21198329 | 0.75 | HTR1A (0.50) | HTR1ASLC6A4DRD2ADRA1ADRD3 | |
| SCHEMBL8332835 | 0.74 | DRD2 (0.56) | HTR1ADRD2ADRA1ADRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054863-B1 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INT RES (NL) | 2003-05-07 | — | — | EP | claimed |
| US-6281216-B1 | 2-aminoquinoline derivatives having d4-agonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2001-08-28 | — | — | US | claimed |
| EP-1054863-A2 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 2000-11-29 | — | — | EP | claimed |
| WO-1999040068-A2 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1999-08-12 | — | — | WO | claimed |
| EP-1054863-B1 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INT RES (NL) | 2003-05-07 | — | — | EP | disclosed |
| US-6281216-B1 | 2-aminoquinoline derivatives having d4-agonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2001-08-28 | — | — | US | disclosed |
| EP-1054863-A2 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040068-A2 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1999-08-12 | — | — | WO | disclosed |