Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6055204 | 0.81 | ALDH1A1 (0.39) | PPARGCSNK1EALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL7143780 | 0.81 | CYP3A4 (0.39) | ALDH1A1CYP3A4CYP2C19KCNH2 | |
| SCHEMBL6055140 | 0.76 | TSHR (0.41) | PPARGALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL9795914 | 0.76 | PPARG (0.48) | PPARGCSNK1EPPARAALDH1A1CYSLTR2 | |
| SCHEMBL22444754 | 0.76 | TSHR (0.50) | PPARGCSNK1EPPARAALDH1A1CYSLTR2 | |
| SCHEMBL4146572 | 0.76 | TSHR (0.50) | PPARGCSNK1EPPARAALDH1A1CYSLTR2 | |
| SCHEMBL8517638 | 0.76 | TSHR (0.50) | PPARGCSNK1EPPARAALDH1A1CYSLTR2 | |
| SCHEMBL22444751 | 0.76 | TSHR (0.50) | PPARGCSNK1EPPARAALDH1A1CYSLTR2 | |
| SCHEMBL3936218 | 0.76 | PPARG (0.48) | PPARGCSNK1EPPARAALDH1A1CYSLTR2 | |
| SCHEMBL6062586 | 0.75 | ADRB2 (0.51) | PPARGCSNK1EPPARACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341745-A1 | RETIFEROL DERIVATIVES AND THEIR USE IN THE TREATMENT OF SKIN DISEASES OR CONDITIONS ASSOCIATED WITH PHOTODAMAGE | F.HOFFMANN-LA ROCHE AG (CH) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002042247-A1 | RETIFEROL DERIVATIVES AND THEIR USE IN THE TREATMENT OF SKIN DISEASES OR CONDITIONS ASSOCIATED WITH PHOTODAMAGE | F.HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | WO | disclosed |