SCHEMBL7145095

SCHEMBL7145095

CC(C)(C)OB(OC(C)(C)C)OC(C)(C)C.[LiH]

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL196117 0.96 ALDH1A1 (0.36) ALDH1A1TSHRTDP1
SCHEMBL2078957 0.92 ALDH1A1 (0.33) ALDH1A1TSHRTDP1
SCHEMBL9387756 0.92 ALDH1A1 (0.33) ALDH1A1TSHRTDP1
Fluoride SCHEMBL15367056 0.92 ALDH1A1 (0.33) ALDH1A1TSHRTDP1
SCHEMBL5732640 0.92 ALDH1A1 (0.33) ALDH1A1TSHRTDP1
Lithium Ion SCHEMBL8992466 0.88 TSHR (0.31) ALDH1A1TSHRTDP1
SCHEMBL27790915 0.77 ALDH1A1 (0.38) ALDH1A1
SCHEMBL2912820 0.77 ALDH1A1 (0.32) ALDH1A1
SCHEMBL5597696 0.72 TSHR (0.41) TSHRTDP1
SCHEMBL12675478 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824113-B2 Supported catalyst, process for its preparation and its use in olefin polymerization BASELL POLYOLEFINE GMBH (DE) 2012-06-27 EP disclosed
EP-0859800-B1 SUPPORTED CATALYST SYSTEM, PROCESS FOR ITS PRODUCTION AND ITS USE IN POLYMERISING OLEFINES BASELL POLYOLEFINE GMBH (DE) 2003-07-23 EP disclosed
US-6271164-B1 METALLOCENE CATALYST LYONDELL CHEMICAL TECHNOLOGY, L.P. 2001-08-07 US disclosed
EP-0824113-B1 Supported catalyst, process for its preparation and its use in olefin polymerization BASELL POLYOLEFINE GMBH (DE) 2001-06-20 EP disclosed
US-6124231-A Supported catalyst system, processes for its preparation, and its use for the polymerization of olefins TARGOR GMBH (DE) 2000-09-26 US disclosed
EP-0859800-A2 SUPPORTED CATALYST SYSTEM, PROCESS FOR ITS PRODUCTION AND ITS USE IN POLYMERISING OLEFINES Basell Polyolefine GmbH (DE) 1998-08-26 EP disclosed
EP-0824113-A1 Supported catalyst, process for its preparation and its use in olefin polymerization HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-18 EP disclosed
WO-1997011775-A2 SUPPORTED CATALYST SYSTEM, PROCESS FOR ITS PRODUCTION AND ITS USE IN POLYMERISING OLEFINES TARGOR GMBH (DE) 1997-04-03 WO disclosed
US-5541327-A Preparation of camptothecin analogs SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1996-07-30 US disclosed
US-5525731-A CYCLIZATION; HALOGENATION; ALKYLATION; REDUCTION; HYDROLYSIS; DECARBOXYLATION; SELENYLATION SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1996-06-11 US disclosed
US-5391745-A Cytotoxic activity towards cancer cells SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1995-02-21 US disclosed
US-5252747-A Chiral quinolone intermediates ABBOTT LABORATORIES (US) 1993-10-12 US disclosed