SCHEMBL7145158

SCHEMBL7145158

CCCOc1cc(C=O)cc(OCc2ccccc2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.61
MAOA P21397 8/20 0.61
RAB9A P51151 2/20 0.49
CCNB2 O95067 1/20 0.49
CDK1 P06493 1/20 0.49
CDK4 P11802 1/20 0.49
CCNB1 P14635 1/20 0.49
CCND1 P24385 1/20 0.49
CCNB3 Q8WWL7 1/20 0.49
NPC1 O15118 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
CYP1A1 P04798 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP19A1 P11511 1/20 0.47
PTGES O14684 1/20 0.46
ALOX5 P09917 1/20 0.46
PPARG P37231 1/20 0.46
TLR4 O00206 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL578947 0.89 MAOB (0.75) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL1748595 0.88 MAOB (0.65) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL1664699 0.86 MAOA (0.75) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL5552613 0.85 MAOB (0.65) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL31388310 0.85 MAOB (0.65) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL273091 0.84 ALDH1A1 (0.44) MEN1KMT2APTGESALOX5PPARG
SCHEMBL16406719 0.82 MAOB (0.65) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL5883252 0.82 MAOA (0.50) MAOBMAOARAB9ACCNB2CDK1
SCHEMBL18882718 0.81 GRM5 (0.54) MAOBMAOARAB9ATDP1MEN1
SCHEMBL1853898 0.81 MAOB (0.69) MAOBMAOARAB9ACCNB2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1115330-C N- (4-amidinophenyl) glycinamide derivatives HOFFMANN LA ROCHE (CH) 2003-07-23 CN disclosed
EP-0921116-B1 N-(4-carbamimido-phenyl)-glycine amide derivatives HOFFMANN LA ROCHE (CH) 2003-06-18 EP disclosed
US-6140353-A USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS HOFFMANN-LA ROCHE INC. (US) 2000-10-31 US disclosed
CN-1224714-A N- (4-amidinophenyl) glycinamide derivatives HOFFMANN LA ROCHE (CH) 1999-08-04 CN disclosed
EP-0921116-A1 N-(4-carbamimido-phenyl)-glycine amide derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-06-09 EP disclosed