Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | P2RY6 | Q15077 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145921 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1ABCC9ABCC8KCNJ11 | |
| SCHEMBL7140517 | 0.87 | PTGS2 (0.46) | PTGS2PTGS1P2RY6ADRA2AADRA2B | |
| SCHEMBL7143166 | 0.85 | PTGS2 (0.43) | PTGS2PTGS1P2RY6ADRA2AADRA2B | |
| SCHEMBL7144308 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1P2RY6ADRA2AADRA2B | |
| SCHEMBL6094101 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL213166 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL29528476 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7145053 | 0.83 | PTGS2 (0.42) | PTGS2PTGS1P2RY6ADRA2ADRD5 | |
| SCHEMBL7147733 | 0.80 | PTGS2 (0.66) | PTGS2PTGS1P2RY6DRD5 | |
| SCHEMBL7142073 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1TSHRP2RY6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977748-B1 | SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2003-03-26 | — | — | EP | claimed |