Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30642883 | 0.87 | SMN1; SMN2 (0.43) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL29666438 | 0.78 | LMNA (0.47) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL17848943 | 0.75 | SMN1; SMN2 (0.36) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL21052670 | 0.75 | KMT2A (0.44) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL1633241 | 0.74 | LMNA (0.56) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL25394536 | 0.73 | SMN1; SMN2 (0.44) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL3738809 | 0.72 | CHRM2 (0.53) | SMN1; SMN2POLBAPEX1BLMMEN1 | |
| SCHEMBL18878053 | 0.72 | CHRM2 (0.53) | SMN1; SMN2POLBAPEX1BLMMEN1 | |
| SCHEMBL6442167 | 0.72 | CHRM2 (0.53) | SMN1; SMN2POLBAPEX1BLMMEN1 | |
| SCHEMBL4049351 | 0.72 | LMNA (0.47) | GBA2SMN1; SMN2LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325146-A2 | PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION | Eidgenössiche Technische Hochschule Zürich (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002031174-A2 | PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION | EIDGENÖSSICHE TECHNISCHE HOCHSCHULE ZÜRICH (CH) | 2002-04-18 | — | — | WO | disclosed |