Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | PPM1D | O15297 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31737625 | 0.89 | LMNA (0.39) | SMN1; SMN2LMNAPOLBGBA2BCHE | |
| SCHEMBL449025 | 0.81 | CHRM2 (0.35) | SMN1; SMN2KDM4E | |
| SCHEMBL433223 | 0.81 | CHRM2 (0.35) | SMN1; SMN2KDM4E | |
| SCHEMBL2133453 | 0.81 | CHRM2 (0.35) | SMN1; SMN2KDM4E | |
| SCHEMBL9596084 | 0.79 | MEN1 (0.30) | GBA2L3MBTL1ALDH1A1 | |
| SCHEMBL8541759 | 0.78 | HPGD (0.43) | SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2724433 | 0.78 | POLB (0.34) | POLBPPM1D | |
| SCHEMBL18581922 | 0.78 | POLB (0.34) | POLBPPM1D | |
| SCHEMBL18581920 | 0.78 | POLB (0.34) | POLBPPM1D | |
| SCHEMBL7145827 | 0.75 | GBA2 (0.44) | SMN1; SMN2LMNAPOLBGBA2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |