Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28974733 | 0.78 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL1736326 | 0.78 | RECQL (0.47) | RECQLEPHX1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL6616011 | 0.78 | ASGR1 (0.32) | MEN1KMT2A | |
| SCHEMBL1186866 | 0.78 | KDM4E (0.50) | RECQLEPHX1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL23249978 | 0.77 | RECQL (0.47) | RECQLEPHX1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL6449345 | 0.76 | RECQL (0.42) | RECQLEPHX1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL7144981 | 0.76 | GPR119 (0.47) | RECQLEPHX1HPGDKDM4EPKM | |
| SCHEMBL13597261 | 0.76 | HPGD (0.49) | RECQLEPHX1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL9311558 | 0.75 | RECQL (0.50) | RECQLEPHX1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL22973125 | 0.74 | RECQL (0.44) | RECQLEPHX1HPGDUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-A1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020483-A1 | PIPERIDINE DERIVATIVES FOR USE 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |