Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172771 | 0.76 | KDM4C (0.44) | ALPLALPIKDM4CNPC1USP2 | |
| SCHEMBL9141452 | 0.73 | HCRTR1 (0.44) | HCRTR1ALPLALPINPC1USP2 | |
| SCHEMBL1913754 | 0.73 | HCRTR1 (0.44) | HCRTR1ALPLALPINPC1USP2 | |
| SCHEMBL15818455 | 0.71 | KDM4C (0.43) | HCRTR1ALPLALPIKDM4CNPC1 | |
| SCHEMBL21655317 | 0.71 | KDM4C (0.43) | ALPLALPIKDM4CNPC1USP2 | |
| SCHEMBL25675893 | 0.71 | KDM4C (0.43) | ALPLALPIKDM4CNPC1USP2 | |
| SCHEMBL7423767 | 0.71 | HCRTR1 (0.44) | HCRTR1ALPLALPIKDM4CNPC1 | |
| SCHEMBL8368454 | 0.70 | KDM4C (0.51) | ALPLALPIKDM4CNPC1USP2 | |
| SCHEMBL31522110 | 0.69 | CYP19A1 (0.49) | KDM4C | |
| SCHEMBL1125535 | 0.69 | CYP19A1 (0.49) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |