Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | TCF4 | P15884 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979802 | 0.86 | LMNA (0.60) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL6979537 | 0.86 | HSD17B3 (0.64) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL6977966 | 0.82 | MAPT (0.70) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL15772389 | 0.82 | MAPT (0.70) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL6976969 | 0.81 | LMNA (0.57) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL16470144 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL5101148 | 0.79 | FFAR4 (0.69) | ALDH1A1LMNAMAPTKDM4EHSD17B10 | |
| SCHEMBL5324234 | 0.79 | KDM4E (0.59) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL25073129 | 0.78 | PTPN11 (0.42) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL25073301 | 0.78 | RXFP1 (0.44) | ALDH1A1LMNAMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |